Is there any way to tie in to Sesame from an IPad?

Also, will Sesame work in the 'Cloud' thing I keep hearing about?

Regarding "the cloud", many cloud providers are running Linux either primarily or (more likely) exclusively, and Sesame will run under Linux. Also, most web hosting companies offer a choice of hosting on Windows-based or Linux-based servers.  However, they generally charge a good bit more to host running software on their servers, because of the increased security problems and the risk of people accidentally screwing something up because of insufficient knowledge of the particular software and operating system, e.g., a Windows user with no Linux/Unix experience trying to set up and run a Linux application.

If you can get it set up and working properly on a Linux box and then move it to a Linux web host, you should be able to move it to a Linux cloud server without much difficulty. It would be best to start by deciding where you expect to ultimately host it and find out what Linux version they use. If you are unfamiliar with Linux, Ubuntu is probably the easiest distro to start with.  However, currently Ubuntu has very little presence in the cloud.  But Canonical (the company that distributes Ubuntu) is working specifically on cloud versions as a major source of revenue.

You will probably find that most major Linux-based cloud providers use a customized version of Linux--after all, if a company is going to support hundreds of thousands of servers, it's easier to design and build what they want than modify someone else's, and the support personnel have CS degrees, so they are comfortable with customization.  Ubuntu is based on Debian. The two commercial "heavyweights" are Red Hat and Novell with its Suse Linux.  Oracle has its own version, as does Google. I think Amazon also has a custom version.